Ingredient
Glycyrrhizinate (licorice) in ZenCortex: What the Label and the Research Say
Monoammonium glycyrrhizinate is the 18th of 22 lines in the ZenCortex Proprietary Herbal Blend, a salt of glycyrrhizin, the sweet compound in licorice root. By label order it can weigh at most 11.1 mg per 1 mL serving, and no amount is printed. NCCIH warns that glycyrrhizin can affect people with high blood pressure, heart or kidney conditions.
Written by the ZenCortex label deskUpdated
The ingredient01
What is glycyrrhizinate in ZenCortex?
Monoammonium glycyrrhizinate is a salt of glycyrrhizin, the sweet compound from licorice root. ZenCortex lists it as line 18 of 22 in its blend.
Licorice root is the plant behind licorice candy flavor. Glycyrrhizin is the part that tastes sweet, and it is also the part that raises safety questions. Salts of it are used as sweeteners and appear in liver research.
The label does not say why this ingredient is in the drops. The info page does not credit it with a hearing claim that we could find. It sits near the end of the list, which already tells you something about its size.
| Name on the label | Monoammonium Glycyrrhizinate |
|---|---|
| What it is | A salt of glycyrrhizin, the sweet compound from licorice root |
| Place on the label | Line 18 of 22 in the 200 mg proprietary blend |
| Amount per serving (1 mL) | At most 11.1 mg per 1 mL serving (label order); 9.1 mg if the 22 lines were split evenly |
| What research used | No safe amount is given on the cited page; glycyrrhizin can matter even in small amounts for some people |
| Strength of evidence | Used as a sweetener and in liver research; nothing on hearing |
| Marketed or traditional use | Licorice-derived ingredient with sweetening and anti-inflammatory uses |
| Main caution | Glycyrrhizin can cause serious effects such as irregular heartbeat; people with high blood pressure, heart or kidney conditions may react to small amounts, and it has interacted with corticosteroids. |
Label position02
How much glycyrrhizinate is in ZenCortex?
The label prints no amount. Glycyrrhizinate is line 18, so label order caps it at 11.1 mg per serving, which is 200 divided by 18.
The cap follows from the weight rule for blends (eCFR, 21 CFR 101.36 Supplement Facts). Each line weighs at least as much as the next, so 18 lines cannot together pass 200 mg and the 18th cannot exceed one eighteenth of it.
Two droppers a day would give at most 22.2 mg. An even split of the blend would be about 9.1 mg per serving, and the label sets no floor.
| Place in the blend | 18 of 22 |
|---|---|
| Most per serving | 11.1 mg |
| Most per day (2 droppers) | 22.2 mg |
| Even split (for comparison) | About 9.1 mg |
| Amount printed | None |
Safety limits03
Is there a safe amount of glycyrrhizin?
The NCCIH page we cite gives no safe amount, and it says some people can react even to small amounts (NCCIH, Licorice Root). So we do not quote a limit.
Glycyrrhizin can cause serious effects such as irregular heartbeat and cardiac arrest, especially with large amounts or long-term use. People with high blood pressure, heart or kidney conditions, or high salt intake may have severe effects even from small amounts.
Whether a salt used at up to 11.1 mg a serving behaves like whole licorice root is not answered by that page. We do not know, and we will not guess. What we can say is that the group that needs to ask first is clearly named.
Evidence04
Does glycyrrhizinate help hearing?
No source we found links glycyrrhizinate to hearing. Our sources describe it as a sweetener and a subject of liver research, not an ear ingredient.
The NCCIH page covers licorice root safety, not hearing. The NIDCD says no supplement has been proven to relieve tinnitus (NIDCD, Tinnitus), and hearing loss that is sudden in one ear is an emergency (NIDCD, Sudden Deafness).
So the fair summary is short: a licorice-derived compound with a safety caution and no hearing evidence.
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See packsCautions05
Who should ask a doctor before taking glycyrrhizinate?
Anyone with high blood pressure, a heart or kidney condition, or a high-salt diet should ask first. NCCIH also says interactions with corticosteroids have been reported, and anyone taking medicines should check with a provider (NCCIH, Licorice Root).
Large oral amounts of licorice in pregnancy are unsafe and may raise the risk of delivery before 38 weeks, per the same page. ZenCortex is already not for anyone pregnant or nursing.
A low ceiling is a small comfort, but it is not a safe harbor for the people in the groups above, because the page says small amounts can matter for them. Show the bottle to your pharmacist (NCCIH, Herb-Drug Interactions).
Never stop or change a blood pressure, heart or kidney medicine because of a supplement. See ZenCortex side effects.
Marketing check06
Why would a hearing formula include a licorice compound?
The label does not say, and neither does the bottle claim. We found no hearing reason in our sources.
A plain reading is that it is one of 22 lines in a long blend that mixes plant extracts, amino acids and GABA. A long list can look thorough. A printed amount for each line would be more useful than a long list.
FDA does not approve supplements before they are sold, and the dagger on the bottle points to the statement that the claim has not been evaluated (FDA, Dietary Supplements).
Keep reading07
Which ingredient page comes next after glycyrrhizinate?
Lines 14 to 17 and 19 to 22 are amino acids and GABA, covered on the amino acids and GABA page. Line 12 is Asian ginseng.
See the supplement facts page and the ZenCortex price guide.
FAQ08
ZenCortex questions people ask
Is monoammonium glycyrrhizinate the same as licorice?
It is a salt of glycyrrhizin, the sweet compound from licorice root, not the whole root. NCCIH's cautions are written about licorice and glycyrrhizin, and whether they apply equally to this salt is not settled.
Can glycyrrhizinate raise blood pressure?
NCCIH says people with high blood pressure may have severe effects from glycyrrhizin even in small amounts, so ask first. The page does not describe a direct blood pressure rise, so we do not claim one.
How much glycyrrhizinate could one ZenCortex dropper hold?
At most 11.1 mg, which is 200 mg divided by 18, because it is listed 18th. The label sets no floor and prints no amount, so the actual figure is unknown. Two droppers a day would double it.
Does licorice interact with steroid medicine?
NCCIH says interactions with corticosteroids have been reported. If you take a steroid, ask your pharmacist about the ZenCortex bottle, and keep taking your steroid exactly as prescribed.
Does glycyrrhizinate have anything to do with hearing?
We found no source that links it to hearing. It is a sweet compound from licorice root used as a sweetener and in liver research, and the bottle does not credit it with a hearing effect.
Can I take ZenCortex with a kidney condition?
Ask your doctor first. NCCIH says people with kidney conditions may have severe effects from glycyrrhizin even at small amounts, and the label tells everyone on a medication or with a condition to consult a physician.
Who wrote this09
Written and reviewed by
Pages built from the label, the sales page and linked NIH, FDA, CDC, FTC and peer-reviewed sources.
Last updated . Read our editorial standards and how we check reviews. This website is run by Thezencortex, a retailer of ZenCortex, not by the manufacturer. We earn money when you buy through our order links.
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