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Glycyrrhizin and Monoammonium Glycyrrhizinate: Licorice Cautions
Glycyrrhizin is the sweet compound in licorice root. ZenCortex lists a salt of it, monoammonium glycyrrhizinate, as line 18 of its 22-line blend. NCCIH warns that glycyrrhizin can cause serious effects such as an irregular heartbeat, and people with high blood pressure, heart or kidney conditions may react to small amounts (NCCIH, Licorice Root).
Written by the ZenCortex label deskUpdated · 4 min read
What is glycyrrhizin, and why is it on the label?
Glycyrrhizin is the sweet-tasting compound from licorice root. Monoammonium glycyrrhizinate is a salt made from it, and it is the 18th of the 22 lines in the ZenCortex blend.
It is used as a sweetener and in liver research. Nothing we found ties it to hearing. The info page does not explain why it is there, and the label does not say.
Is glycyrrhizin safe for blood pressure and the heart?
Not for everyone. NCCIH says glycyrrhizin can cause serious effects, including an irregular heartbeat and cardiac arrest, mostly with large amounts or long use (NCCIH, Licorice Root).
The same page says people with high blood pressure, a heart or kidney condition, or a high salt intake may have severe effects even from small amounts. It also reports interactions with corticosteroids.
That page does not mention potassium or describe a direct rise in blood pressure, so we do not claim either here. We cannot say how much glycyrrhizinate one dropper delivers, which is the real problem for someone in a risk group.
| Situation | Why ask |
|---|---|
| High blood pressure | May react to small amounts |
| Heart or kidney condition | May react to small amounts |
| Taking a corticosteroid | Interactions reported |
| Pregnant | Large oral amounts called unsafe |
How much glycyrrhizinate is in one dropper?
The amount of glycyrrhizinate in one ZenCortex dropper is not printed. By the label-order rule (eCFR, 21 CFR 101.36 Supplement Facts), line 18 can weigh at most 200 divided by 18, or 11.1 mg.
An even split of the 200 mg blend would be about 9.1 mg per line. The truth is anywhere up to the ceiling, and the label gives no way to tell. The bar below shows the blend cut into 22 pieces, one of them this ingredient.
The arithmetic for twice a day is short. At the ceiling, two droppers give up to 22.2 mg a day. At an even split, they give about 18.2 mg. Whether either figure matters depends on your health, which is why a pharmacist should see the label.
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See packsWhat should you do before buying a licorice-containing supplement?
Show the label to your pharmacist before you buy. The ZenCortex label itself says to consult a physician, especially with a medication or a medical condition.
Keep taking prescribed medicine, and never change a dose because of a supplement. Our guide to supplements and medicines and the side effects page cover more, and the glycyrrhizinate page has the ingredient card.
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FAQ01
ZenCortex questions people ask
What is the difference between glycyrrhizin and glycyrrhizinate?
Glycyrrhizin is the sweet compound found in licorice root, and monoammonium glycyrrhizinate is a salt made from it. NCCIH discusses glycyrrhizin; we found no separate safety page for the salt, so treat the same cautions as the starting point.
Does deglycyrrhizinated licorice avoid the problem?
Deglycyrrhizinated licorice has had the glycyrrhizin removed, and NCCIH says it might be safe for up to four months. ZenCortex lists glycyrrhizinate, not the deglycyrrhizinated form, so that note does not apply to this label (NCCIH, Licorice Root).
Is black licorice candy a concern too?
The NCCIH page we cite covers licorice root products and does not discuss candy. It does say glycyrrhizin effects can follow large amounts or long use, so anyone in a risk group should ask a clinician about all licorice sources.
Who wrote this02
Written and reviewed by
Pages built from the label, the sales page and linked NIH, FDA, CDC, FTC and peer-reviewed sources.
Last updated . Read our editorial standards and how we check reviews. This website is run by Thezencortex, a retailer of ZenCortex, not by the manufacturer. We earn money when you buy through our order links.
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